Intermittent Fasting and Time-Restricted Eating in Diabetes Management: Evidence, Mechanisms, and Clinical Implications
Intermittent Fasting and Time-Restricted Eating in Diabetes Management: Evidence, Mechanisms, and Clinical Implications
Author(s):Himani Nagar, Swamita Arora, Nikhil Raghav, Sanjar Alam
Received: June 26, 2023
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Accepted: July 15, 2026
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Published:
July 23, 2026
Abstract
Background: Impaired glucose metabolism, obesity, cardiovascular problems, and a lower quality of life are all linked to diabetes mellitus, a significant global health concern. Due to uneven results and poor long-term adherence, conventional dietary regimens frequently have drawbacks. Time-restricted feeding (TRF) and intermittent fasting (IF) have become popular nutritional approaches for enhancing glycaemic management and metabolic health.
Objective: The purpose of this study is to assess the available data on the efficacy, mechanisms, therapeutic advantages, and safety issues of IF and TRF in the treatment of diabetes mellitus.
Methods: Clinical trials, observational studies, and mechanistic research examining several IF and TRF protocols, such as 16:8 fasting, the 5:2 diet, alternate-day fasting, and early time-restricted eating, were the main focus of a thorough assessment of available literature. Analysis was done on pertinent results pertaining to body weight, insulin sensitivity, glucose regulation, and cardiometabolic health.
Results: Research suggests that IF and TRF can enhance insulin sensitivity, decrease hepatic glucose production, increase autophagy, alter gut microbiota, and improve hormone regulation in order to improve glycaemic management. Fasting blood glucose, HbA1c levels, body weight, blood pressure, inflammatory indicators, and lipid abnormalities have all decreased, according to clinical research. However, there may be hazards including hypoglycemia, nutritional deficits, exhaustion, and difficulties with adherence, especially in older people, expectant mothers, and patients on glucose-lowering drugs.
Conclusion: In conclusion, when properly tailored and under medical supervision, IF and TRF are useful supplemental dietary approaches for managing diabetes. Although patient selection, monitoring, and expert supervision are still necessary for safe and effective implementation, their benefits go beyond glucose management to include overall cardiometabolic health.
Objective: The purpose of this study is to assess the available data on the efficacy, mechanisms, therapeutic advantages, and safety issues of IF and TRF in the treatment of diabetes mellitus.
Methods: Clinical trials, observational studies, and mechanistic research examining several IF and TRF protocols, such as 16:8 fasting, the 5:2 diet, alternate-day fasting, and early time-restricted eating, were the main focus of a thorough assessment of available literature. Analysis was done on pertinent results pertaining to body weight, insulin sensitivity, glucose regulation, and cardiometabolic health.
Results: Research suggests that IF and TRF can enhance insulin sensitivity, decrease hepatic glucose production, increase autophagy, alter gut microbiota, and improve hormone regulation in order to improve glycaemic management. Fasting blood glucose, HbA1c levels, body weight, blood pressure, inflammatory indicators, and lipid abnormalities have all decreased, according to clinical research. However, there may be hazards including hypoglycemia, nutritional deficits, exhaustion, and difficulties with adherence, especially in older people, expectant mothers, and patients on glucose-lowering drugs.
Conclusion: In conclusion, when properly tailored and under medical supervision, IF and TRF are useful supplemental dietary approaches for managing diabetes. Although patient selection, monitoring, and expert supervision are still necessary for safe and effective implementation, their benefits go beyond glucose management to include overall cardiometabolic health.
Keywords: insulin sensitivity, glycaemic control, time-restricted feeding, diabetes mellitus, intermittent fasting, metabolic health, and dietary intervention
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