All embryonic, foetal, and adult stem cells are undifferentiated cells that give rise to differentiated cells that form the structure of tissues and organs. Throughout the postnatal and adult phases of life, differentiated organs contain tissue-specific stem cells that play a crucial role in organ regeneration after injury. The primary features of stem cells are (a) clonality, which often originates from a single cell, (b) potency, which can differentiate into several cell types, and (c) self-renewal, which allows for significant proliferation. It's possible that different stem cells have different characteristics. Because they would not multiply widely and can only develop into tissue-specific cells, adult tissue stem cells have limited capacity for self-renewal, whereas embryonic stem cells (ESCs) generated from the blastocyst have more potency and capacity for self-renewal. Endoderm, Mesoderm, and Ectoderm are the germ layers from which ESCs are formed during the development of the human body, starting with the zygote and blastocyst. Particular organs emerge from the germ layers. Progenitor cells that have helped develop organs include those present in bone marrow, bone, blood, muscle, liver, brain, adipose tissue, skin, and the gastrointestinal tract. These cells do not eventually differentiate; instead, they remain tissue stem cells [1, 2]. Given their ability to produce terminally differentiated and specialised cells within the tissue or organ, tissue stem cells may also be referred to as progenitor cells. These cells could be quiescent in the tissue, but in situations involving damage and healing, they would multiply [3-5]. The dynamics of tissue stem cells, also known as progenitor cells, differ depending on the tissue. For instance, stem cells regularly proliferate in the bone marrow, liver, lung, and gut to supplement cells during normal turnover or injury [6–9], whereas they do the same in the pancreas, heart, or nervous system to replace damaged cells after injury [10–14]. Ancient Greek mythology about the Greek titan Prometheus reflects the concept of organ regeneration and wound healing, which is as old as humanity

New therapeutic treatments and the creation of reasonably priced, efficient medications are necessary for the country's health to continue improving. With treatments that promote in vivo regeneration and the in vitro production of healthy tissue for implantation, regenerative medicine holds the promise of curing a plethora of deadly and crippling illnesses. In the next 20 years, the next phase of medical technology development could materialize. It is currently in sight. Regenerative medicine is a field that science will inevitably advance, but it will take too long for the technology to catch up without direction. To understand regenerative medicine and bring this technology to market within the next 20 years, Initiative for Regenerative Medicine is needed.